Papaverine and hepatotoxicity.
نویسندگان
چکیده
Six of 14 patients receiving a sustained release papaverine preparation developed abnormal liver function tests. One patient had jaundice and another abnormal liver histology on a biopsy specimen. This is only the third report of impaired liver function following the administration of papaverine--a drug which has been used in clinical medicine for over 100 years.
منابع مشابه
مقایسه سرعت حداکثر سیستولی شریان کاورنوزال پنیس قبل و بعد از تزریق پاپاورین در اختلال نعوظ
Background: Sexual dysfunction in males is characterized by the inability to achieve or maintain an erection sufficient for a satisfactory sexual activity. Erectile dysfunction is a common disorder in males and intracavernosal injection of papaverine followed by color Doppler ultrasonography of the penis is used to diagnose and treat vascular impotence. In this study, we examined the relationsh...
متن کاملIntra- and post-operational changes in pupils induced by local application of cisternal papaverine during cerebral aneurysm operations.
AIM To investigate the effect of locally administered intracisternal papaverine on the pupils during cerebral aneurysm clipping. MATERIAL AND METHODS Four patients that received cerebral aneurysm clipping were included in the study. Papaverine (3%, 60 mg) was dropped into the internal carotid artery cistern to relieve vascular spasm and act on the oculomotor nerve intentionally at the same ti...
متن کاملPapaverine blocks hKv1.5 channel current and human atrial ultrarapid delayed rectifier K+ currents.
Papaverine, 1-[(3,4-dimethoxyphenyl)methyl]-6,-7-dimethoxyisoquinoline, has been used as a vasodilator agent and a therapeutic agent for cerebral vasospasm, renal colic, and penile impotence. We examined the effects of papaverine on a rapidly activating delayed rectifier K(+) channel (hKv1.5) cloned from human heart and stably expressed in Ltk(-) cells as well as a corresponding K(+) current (t...
متن کاملProconvulsant effect of papaverine on penicillin-induced epileptiform activity in rats.
AIM Papaverine is a vasodilator agent that is an opium alkaloid. It exhibits its effects by inhibiting phosphodiesterase enzyme. Papaverine administration is widely used to avoid symptomatic vasospasm after subarachnoid hemorrhage. We aim in this research to study the effects of papaverine on the epileptic discharges stimulated by penicillin. MATERIAL AND METHODS Adult female Wistar rats (220...
متن کاملInhibitory effect of papaverine on HVJ (Sendai virus) replication in rat glioma C6 cells.
The replication of HVJ (Sendai virus) in C6 rat glial cells was found to be inhibited by treatment of the cells with papaverine, an inhibitor of cAMP phosphodiesterase, but not with cAMP or dibutyryl cAMP. In addition, cyclic GMP which often manifests a reciprocal relationship to cAMP did not counteract the inhibition of HVJ yield by papaverine. Both viral genome replication and transcription w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 56 657 شماره
صفحات -
تاریخ انتشار 1980